A Grey’s Anatomy fan favorite is set to make a shock return in season 22. The long-running ABC medical drama has boasted a wealth of memorable characters over the course of its run, with a huge ensemble cast that has evolved over the years, around series star and lead actor Ellen Pompeo.

The Grey’s Anatomy cast has produced some intriguing character dynamics across the years, with many of them affecting Pompeo’s Meredith Grey in different ways. In recent seasons, Meredith’s growing obsession with Alzheimer’s research has brought her into conflict with several characters, one of whom was in the Grey’s Anatomy season 21 premiere.

Per TV Promos teaser trailer, Jesse Williams’s popular character, Jackson Avery, is set to return to the show for the upcoming Grey’s Anatomy season 22 episode “Goodbye Horses.” The clip shows a tense reunion between Jackson and Meredith, as the two friends clash over her Alzheimer’s research. Check out the clip below:

Meredith and Jackson are friends, but their relationship has been tested during this time, and Meredith keeps elements of her research hidden from him. His return in the season 21 premiere, to try to solve the conflict between Meredith and Catherine, wound up with the former freezing him out over her work.

Jackson’s arc wasn’t closed out after that episode, leaving the need for a return in season 22. Given that the promo shows his return and a confrontation with Meredith, there’s sure to be plenty of fallout from their clash. What’s more, though Meredith kept Catherine’s secret was morally correct, it did break Jackson’s trust, adding another layer of tension.

It’s unclear how Jackson’s return is going to impact the course of Grey’s Anatomy season 22, and even how long he might be a part of the new season. The return of such an iconic character is certainly going to be a shot in the arm for the season, and allows Grey’s to return to what it does best — conflict between its main characters.

A Grey’s Anatomy fan favorite is set to make a shock return in season 22. The long-running ABC medical drama has boasted a wealth of memorable characters over the course of its run, with a huge ensemble cast that has evolved over the years, around series star and lead actor Ellen Pompeo.

The Grey’s Anatomy cast has produced some intriguing character dynamics across the years, with many of them affecting Pompeo’s Meredith Grey in different ways. In recent seasons, Meredith’s growing obsession with Alzheimer’s research has brought her into conflict with several characters, one of whom was in the Grey’s Anatomy season 21 premiere.

Per TV Promos teaser trailer, Jesse Williams’s popular character, Jackson Avery, is set to return to the show for the upcoming Grey’s Anatomy season 22 episode “Goodbye Horses.” The clip shows a tense reunion between Jackson and Meredith, as the two friends clash over her Alzheimer’s research. Check out the clip below.

Meredith and Jackson are friends, but their relationship has been tested during this time, and Meredith keeps elements of her research hidden from him. His return in the season 21 premiere, to try to solve the conflict between Meredith and Catherine, wound up with the former freezing him out over her work.

Jackson’s arc wasn’t closed out after that episode, leaving the need for a return in season 22. Given that the promo shows his return and a confrontation with Meredith, there’s sure to be plenty of fallout from their clash. What’s more, though Meredith kept Catherine’s secret was morally correct, it did break Jackson’s trust, adding another layer of tension.

It’s unclear how Jackson’s return is going to impact the course of Grey’s Anatomy season 22, and even how long he might be a part of the new season. The return of such an iconic character is certainly going to be a shot in the arm for the season, and allows Grey’s to return to what it does best — conflict between its main characters.

It’s clear that Jackson still has unfinished business at Grey Sloan Memorial, and given that he’s the reason Meredith’s Alzheimer’s research was possible to begin with, this is his story to finish. If the two can bury the hatchet, which feels likely, things can get back on track, and help Meredith’s research even further, and help make a difference again.