Now, Dane is back on another medical drama, where he’ll guest star in Brilliant Minds season 2, episode 9, “The Fire Fighter.” His character, Matthew, is a firefighter with Amyotrophic Lateral Sclerosis (ALS), the same neurodegenerative condition that the actor has. The storyline will revolve around Matthew grappling with how to reveal his medical diagnosis to his family.

Matthew’s ex-wife, Alicia, and daughter, Gabby, will be played by Mädchen Amick and Chloe Avakian, respectively.

TVInsider revealed four photos from this episode of Brilliant Minds season 2 that give a teaser of what to expect from Dane’s guest appearance. The first photo shows Dane’s character, Matthew, sitting against a fire truck as his ex-wife wears a concerned expression while looking at Dr. Oliver Wolf, a neurologist played by star Zachary Quinto.

The second photo is a close-up shot of Dane’s character, Matthew. The final two photos show Matthew, Alicia, and daughter Gabby in the doctor’s office while discussing with Dr. Wolf and Dr. Carol Pierce, played by co-star Tamberla Perry.

In some of the images, Gabby can be seen typing on her phone, possibly to take notes as the doctors are speaking or to look up more info about her father’s condition. Check out the Brillians Minds photos with Dane below:

This Brilliant Minds storyline is definitely an art-imitates-life situation since Dane was diagnosed with ALS back in the spring. ALS is a degenerative condition that involves the loss of muscle control. There is no cure for ALS. Throughout 2025, Dane has been open about his diagnosis and symptoms, with the actor losing the ability to move his right hand and arm. He started using a wheelchair later in the year.

Grey’s Anatomy was the project that put Dane on the map in Hollywood. His character, Sloan, played a major role in the series as Derek Shepherd’s best friend, who had an affair with his wife. After leaving the long-running medical drama, Dane appeared in multiple movies and had starring roles on TV shows like The Last Ship, Euphoria, and Countdown.

He’s expected to appear in Euphoria season 3, which will air sometime in 2026. Before his return, though, Dane will guest star on Brilliant Minds this fall. It’ll surely be an emotional episode for Brilliant Minds and Dane fans alike.